In the documents, seen by Mirror Online, Giuffre, now 36, recalled in her memoir manuscript that Maxwell spoke of an alleged incident with Clooney in 2001 during a trip the two women were on.
But it is not known if this was when the encounter with Clooney, who is now married to barrister Amal, may have taken place or some time before.
“Once she came back giddy as a schoolgirl with an explosion of news, with all the build up and excitement in her voice you’d think she was the next crown princess, but she had given George Clooney a b*** job in the bathroom at some random event, she never let that one down.”
Numerous news outlets have contacted reps for George Clooney for comment with none forthcoming.
The manuscript was written in 2011 and used as part of the legal wrangling in the US between the pair as they battled out Giuffre’s 2015 defamation case against Maxwell.
The case was eventually settled in 2017 and the documents were sealed until last week.
Epstein, 66, who was jailed for child prostitution in 2008, was found hanged on Saturday just hours after the depths of his abuse were laid bare in previously unseen documents.
The papers include depositions, police reports, photographs and a memoir written by a woman who said she was a sex-trafficking victim of the billionaire and his friends.
Epstein, who was arrested on July 6, had pleaded not guilty to charges of sex trafficking involving dozens of underage girls as young as 14, from at least 2002 to 2005.
He previously admitted prostituting minors in 2008 and spent 18 months in prison after agreeing a plea bargain.
Ghislaine, 57, who is the youngest child of disgraced media tycoon Robert Maxwell, started dating Epstein in 1992.
It was claimed she actively took part in recruiting young women for sex with Epstein, as well as scheduling the girls to come over, and maintaining a list of their names and numbers.
It was said she was known as the “madam” by the alleged victims.
Maxwell has repeatedly denied the allegations against her and has not yet been arrested.